Regiospecific and Stereoselective Syntheses of (.+-.)-Reserpine and (-)-Reserpine.

Reserpine and cerebral vasospasm.

Cerebral vasospasm was produced in the dog basilar artery by topically applied five-day-old clotted autologous blood, but not by freshly drawn blood. The spasm was reversed by methysergide, an antiserotonin agent. However, vasospasm was not produced by five-day-old clotted autologous blood from dogs pretreated with reserpine. This suggests platelet serotonin or a similar, unidentified substance...

Treatment of hypertension with reserpine, with reserpine in combination with pentapyrrolidinium, and with reserpine in combination with Veratrum alkaloids.

The treatment of hypertension with reserpine is described. When used alone it produced adequate falls of blood pressure in ten out of forty patients. The combination of reserpine with veratrum did not increase the hypotensive effects of reserpine alone. The combination of reserpine with pentapyrrolidinium increases the effectiveness of the pentapyrrolidinium and lessens its para-sympathetic sid...

Effects of Reserpine Therapy

The effects of long-term reserpine therapy (1) on cardiac output during rest and induced atrial tachycardia and (2) on atrioventricular (A-V) conduction were examined in a group of eight men with previously untreated essential hypertension. The patients were studied before and after 20 to 205 days of reserpine therapy. All studies were performed in the cardiopulmonary laboratory with the patien...

Hypotensive Action of Reserpine

The effects of large doses of reserpine have been compared in hypertensive and norrmotensive patients. The falls of blood pressure are larger in the hvpertensives than in the normotensives. In normotensive animals small falls of blood pressure occur. Evidence is presented which suggests that the fall of blood pressure in animals is in part mediated through the sympathetic nervous system. There ...

Use of reserpine and Rauwolfia in psychoneuroses.